H63D polymorphism in HFE is not associated with amyotrophic lateral sclerosis

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The association between H63D mutations in HFE and amyotrophic lateral sclerosis in a Dutch population.

BACKGROUND Mutations in HFE, a gene defect that can disrupt iron metabolism, have been implicated in increasing the risk of developing amyotrophic lateral sclerosis (ALS). OBJECTIVE To further establish the association between ALS and HFE mutations by investigating whether HFE mutations are associated with an increased risk of developing ALS in a population in The Netherlands and by pooling o...

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Abstract Lead is a heavy metal that affects many organs such as nervous system, liver, and kidney. The most important affected organ is central nervous system. The present study reported a case similar to Amyotrophic lateral sclerosis (ALS) due to lead exposure in an opium addicted person. The patient complaint was the weakness of upper and lower limbs in addition to the unsteadiness of gait...

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ژورنال

عنوان ژورنال: Neurobiology of Aging

سال: 2013

ISSN: 0197-4580

DOI: 10.1016/j.neurobiolaging.2012.07.020